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Biological Data

Biological description PP 2 (Src kinase inhibitor) negative control. Does not inhibit Src family kinases. Inhibits EGFR kinase and CK1δ (IC50 values are 2.7 and 9.9 µM respectively).

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM) or ethanol (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Molecular Weight 211.22
Molecular Formula C11H9N5
CAS Number 5334-30-5
PubChem identifier 4879
SMILES NC1=NC=NC2=C1C=NN2C3=CC=CC=C3
InChiKey KKDPIZPUTYIBFX-UHFFFAOYSA-N

References for PP 3

References are publications that support the biological activity of the product
  • Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173.

    Kong L et al (2011) Mol Cell Biochem 348(1-2) : 11-9.
  • The specificities of protein kinase inhibitors: an update.

    Bain J et al (2003) Biochem J 371(Pt 1) : 199-204.
  • Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines.

    Traxler P et al (1997) J Med Chem 40(22) : 3601-16.

3 Item(s)