PPT
(HB2499)- Data
- Support & Resources
Data
Product overview
-
NamePPT
-
Short descriptionSelective ERα estrogen receptor agonist
-
Biological descriptionSelective ERα estrogen receptor agonist (Kd values are 2 and 1000 nM at ERα and ERβ respectively). Displays a 410-fold higher selectivity for ERα over ERβ. Shows neuroprotective effects. Active in vivo.
-
Biological actionAgonist
-
Purity>99%
- Citations
Properties
-
Chemical name4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol
-
Molecular Weight386.45
-
Chemical structure
-
Molecular FormulaC24H22N2O3
-
CAS Number263717-53-9
-
PubChem identifier6095481
-
SMILESCCCC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O
-
InChiInChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3
-
InChiKeyUOSWGERPQQOSHS-UHFFFAOYSA-N
-
MDL numberMFCD03453628
Storing and Using Your Product
-
Storage instructions+4°C
-
Solubility overviewSoluble in DMSO (100 mM)
-
ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for PPT
Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS.
Sepehr E et al (2012) J Pharm Biomed Anal 71 : 119-26.PubMedID: 22981216Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons.
Zhao L et al (2004) Brain Res 1010(1-2) : 22-34.PubMedID: 15126114The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease.
Baraka AM et al (2011) Life Sci 88(19-20) : 879-85.PubMedID: 21420980
Support & Resources