PPT

(HB2499)

(HB2499)

Data

Product overview

Name
PPT
Short description
Selective ERα estrogen receptor agonist
Biological description
Selective ERα estrogen receptor agonist (K_d values are 2 and 1000 nM at ERα and ERβ respectively). Displays a 410-fold higher selectivity for ERα over ERβ. Shows neuroprotective effects. Active in vivo.
Biological action
Agonist
Purity
>99%
Citations
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Chemical name
4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol
Molecular Weight
386.45
Chemical structure
Molecular Formula
C₂₄H₂₂N₂O₃
CAS Number
263717-53-9
PubChem identifier
6095481
SMILES
CCCC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O
InChi
InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3
InChiKey
UOSWGERPQQOSHS-UHFFFAOYSA-N
MDL number
MFCD03453628

Storage instructions
+4°C
Solubility overview
Soluble in DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS.
Sepehr E et al (2012) J Pharm Biomed Anal 71 : 119-26.
PubMedID: 22981216
Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons.
Zhao L et al (2004) Brain Res 1010(1-2) : 22-34.
PubMedID: 15126114
The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease.
Baraka AM et al (2011) Life Sci 88(19-20) : 879-85.
PubMedID: 21420980

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