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Data

Product overview

  • Name
    PPT
  • Short description
    Selective ERα estrogen receptor agonist
  • Biological description
    Selective ERα estrogen receptor agonist (Kd values are 2 and 1000 nM at ERα and ERβ respectively). Displays a 410-fold higher selectivity for ERα over ERβ. Shows neuroprotective effects. Active in vivo.
  • Biological action
    Agonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol
  • Molecular Weight
    386.45
  • Chemical structure
    PPT [263717-53-9]
  • Molecular Formula
    C24H22N2O3
  • CAS Number
    263717-53-9
  • PubChem identifier
    6095481
  • SMILES
    CCCC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O
  • InChi
    InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3
  • InChiKey
    UOSWGERPQQOSHS-UHFFFAOYSA-N
  • MDL number
    MFCD03453628

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PPT

  • Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS.

    Sepehr E et al (2012) J Pharm Biomed Anal 71 : 119-26.
    PubMedID: 22981216
  • Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons.

    Zhao L et al (2004) Brain Res 1010(1-2) : 22-34.
    PubMedID: 15126114
  • The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease.

    Baraka AM et al (2011) Life Sci 88(19-20) : 879-85.
    PubMedID: 21420980
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