Differentiation
Stem cells such as induced pluripotent stem cells (iPSCs) and human embryonic stem (ESCs) are differentiated into specialized cell types for applications including drug discovery, disease modeling and cell therapy. Small molecules may be used to modulate signaling pathways which affect stem cell differentiation. Researchers can save up to 50% on high purity stem cell differentiation research products - they are up to half the price of other suppliers.
View products: iPSCs & ESCs | Mesenchymal Stem cells (MSCs) | Neural Stem Cells (NSCs)
A83-01 (HB3218)
Description:Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self renewal, 3D growth matrix component and promotes long-term organoid growth. Aids fibroblast to NSC/cardiomyocyte reprogramming.
Purity:>98%
-
5-Azacytidine (HB1374)
Description:DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.
Purity:>98%
-
CCG 1423 (HB3389)
Description:Rho/SRF pathway inhibitor. Induces intermediate mesoderm differentiation from ESCs.
Purity:>99%
-
CHIR 99021 (HB1261)
Description:Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.
Purity:>98%
-
Cyclopamine (HB2965)
Description:Smo and hedgehog (Hh) signaling inhibitor. Also depletes stem like cancer cells and induces hESCs into endocrine cells.
Purity:>98%
-
DAPT (HB3345)
Description:γ-secretase inhibitor and classical notch inhibitor. Induces neuronal differentiation. 3D Growth matrix component and used in cerebral organoid differentiation media.
Purity:>98%
-
-
Dorsomorphin dihydrochloride (HB2800)
Description:Potent, selective AMPK inhibitor. Promotes neural hPSCs differentiation and promotes cardiomyocyte differentiation in mESCs.
Purity:>98%
-
EHNA hydrochloride (HB3540)
Description:Potent adenosine deaminase and PDE2 inhibitor. Supresses spontaneous hESC differentiation. Also maintains pluripotency of hESCs in the absence of exogenous cytokines.
Purity:>98%
-
Fluoxetine hydrochloride (HB1600)
Description:Selective 5-HT uptake inhibitor. Affects differentiation of NSCs.
Purity:>98%
