Novel tool for studying GPCR desensitization
An exclusive from Hello Bio, Cmpd101 is a novel, potent, selective G-protein coupled receptor kinase 2 and 3 inhibitor (IC50 values are 35, 290 nM and 125 µM at GRK2, GRK3 and GRK5 respectively). Selective over other kinases. Can be used to study roles of GRK2/3 in GPCR desensitization...Read more
GABAA receptors are ligand gated Cys-loop family ion channels (ionotropic receptors) that form a pentameric intrinsic anion channel. In mammals, 6α, 3β, 3γ, 1δ, 3ρ, 1ε, 1π and 1θ subunits have been identified. GABAA receptors are comprised of predominately the α-, β- and γ-subunits, but a subgroup of GABAA receptors are formed exclusively from ρ subunits. Researchers can save 50% on GABAA receptor agonists, antagonists and allosteric modulators from Hello Bio - they are up to half the price of other suppliers.