Metabotropic glutamate receptors (mGluRs) are GPCRs with important roles in learning and memory, pain, epilepsy and more. Selective agonists, antagonists, and positive and negative allosteric modulators (PAMs and NAMs) have been developed for Group I (mGlu1 and mGlu5), Group II (mGlu2 and mGlu3) and Group III (mGlu4, mGlu6, mGlu7 and mGlu8) receptors. This mini-review summarises the structure, function and pharmacology of mGluRs to date...
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GABAA receptors are ligand gated Cys-loop family ion channels (ionotropic receptors) that form a pentameric intrinsic anion channel. In mammals, 6α, 3β, 3γ, 1δ, 3ρ, 1ε, 1π and 1θ subunits have been identified. GABAA receptors are comprised of predominately the α-, β- and γ-subunits, but a subgroup of GABAA receptors are formed exclusively from ρ subunits. Researchers can save 50% on GABAA receptor agonists, antagonists and allosteric modulators from Hello Bio - they are up to half the price of other suppliers.