Metabotropic glutamate receptors (mGluRs) are GPCRs with important roles in learning and memory, pain, epilepsy and more. Selective agonists, antagonists, and positive and negative allosteric modulators (PAMs and NAMs) have been developed for Group I (mGlu1 and mGlu5), Group II (mGlu2 and mGlu3) and Group III (mGlu4, mGlu6, mGlu7 and mGlu8) receptors. This mini-review summarises the structure, function and pharmacology of mGluRs to date...
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AMPA receptors are members of the ionotropic class of glutamate receptors and consist of GluA1 (formerly GluR1), GluA2 (formerly GluR2), GluA3 (formerly GluR3) and GluA4 (formerly GluR4) subunits.They assemble as homomers or heteromers to form functional AMPA receptors. Researchers can save 50% on AMPA receptor agonists, antagonists and allosteric modulators from Hello Bio - they are up to half the price of other suppliers.