Novel tool for studying GPCR desensitization
An exclusive from Hello Bio, Cmpd101 is a novel, potent, selective G-protein coupled receptor kinase 2 and 3 inhibitor (IC50 values are 35, 290 nM and 125 µM at GRK2, GRK3 and GRK5 respectively). Selective over other kinases. Can be used to study roles of GRK2/3 in GPCR desensitization...Read more
Acetylcholine (ACh) muscarinic receptors are a family of G-protein coupled receptors classified into M1, M2, M3, M4 and M5 muscarinic receptors. M2 and M4-muscarinic receptors couple to the pertusiss-toxin sensitive Gi/o-proteins, and M1, M3 and M5-muscarinic receptors couple to Gq/11-proteins. Researchers can save up to 50% on ACh muscarinic receptor agonists, antagonists and modulators from Hello Bio - they are up to half the price of other suppliers.