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DREADD

Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).

  1. Clozapine

    Clozapine(HB1607)

    Reviews:
    Description:

    Prototypic, atypical antipsychotic, binds to both serotonin and dopamine receptors

    Purity :

    >99%

    Pack: Price: Qty:
    50mg
    $85
    500mg
    $350
  2. Clozapine dihydrochloride (water soluble)
    Reviews:
    Description:

    Water soluble prototypic, atypical antipsychotic. Binds to both serotonin and dopamine receptors.

    Purity :

    >98%

    Pack: Price: Qty:
    10mg
    $37
    50mg
    $96
  3. Clozapine N-oxide (CNO) (freebase)
    Reviews:
    Description:

    Prototypical DREADD activator. Clozapine metabolite.

    Purity :

    >98%

    Pack: Price: Qty:
    5mg
    $50
    10mg
    $85
    25mg
    $185
    100mg
    $650
  4. Clozapine N-oxide (CNO) dihydrochloride (water soluble)
    Reviews:
    Description:

    Dihydrochloride salt of CNO - the prototypical DREADD activator

    Purity :

    >98%

    Pack: Price: Qty:
    5mg
    $45
    10mg
    $77
    25mg
    $167
    100mg
    $585
  5. DREADD agonist 21 (Compound 21) dihydrochloride (water soluble)
    Reviews:
    Description:

    Effective agonist for muscarinic-based DREADDs in vitro and in vivo. Non-CNO chemogenetic actuator. Brain penetrant. Water soluble.

    Purity :

    >98%

    Pack: Price: Qty:
    5mg
    $63
    10mg
    $113
    25mg
    $259
    100mg
    $943
  6. DREADD agonist 21 (Compound 21)
    Description:

    Effective agonist for muscarinic-based DREADDs in vitro and in vivo. Non-CNO chemogenetic actuator. Brain penetrant.

    Purity :

    >98%

    Pack: Price: Qty:
    5mg
    $55
    10mg
    $98
    25mg
    $225
    100mg
    $820
  7. Description:

    Novel DREADD ligand with high affinity and potency for hM3Dq and hM4Di. Active in vivo.

    Purity :

    >98%

    Pack: Price: Qty:
    5mg
    $70
    10mg
    $135
    25mg
    $285
    100mg
    $1,049
  8. Description:

    Novel water soluble DREADD ligand with high affinity and potency for hM3Dq and hM4Di. Active in vivo.

    Purity :

    >98%

    Pack: Price: Qty:
    5mg
    $70
    10mg
    $135
    25mg
    $285
    100mg
    $1,049
  9. Description:

    Novel DREADD ligand with high affinity and potency for hM3Dq and hM4Di. Active in vivo.

    Purity :

    >98%

    Pack: Price: Qty:
    5mg
    $70
    10mg
    $135
    25mg
    $285
    100mg
    $1,049
  10. Description:

    Novel water soluble DREADD ligand with high affinity and potency for hM3Dq and hM4Di. Active in vivo.

    Purity :

    >98%

    Pack: Price: Qty:
    5mg
    $70
    10mg
    $135
    25mg
    $285
    100mg
    $1,049