Psalmotoxin 1

(HB1148)

Product overview

  • Name
    Psalmotoxin 1
  • Short description
    Potent, selective ASIC1a blocker
  • Biological description
    Potent and selective acid sensing (proton gated) ion channel 1a (ASIC1a) blocker (IC50 = 0.9 nM). Shows antinociceptive and neuroprotective actions.
  • Biological action
    Blocker
  • Our products in action

Images

Properties

  • Molecular Weight
    4689.41
  • Molecular Formula
    C200H312N62O57S6

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in water (2mg/ml)

References for Psalmotoxin 1

  • Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.

    Escoubas P et al (2000) J Biol Chem 275(33) : 25116-21.
    PubMedID: 10829030
  • A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.

    Mazzuca M et al (2007) Nat Neurosci 10(8) : 943-5.
    PubMedID: 17632507
  • Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia-ischemia in newborn piglet striatum.

    Yang ZJ et al (2011) Neurobiol Dis 43(2) : 446-54.
    PubMedID: 21558004
The following papers have cited the use of Psalmotoxin 1 (HB1148) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus

    Mango et al(2017) Pharmacological Research : In press

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