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Puromycin dihydrochloride

(HB4041)
Data

Product overview

  • Name
    Puromycin dihydrochloride
  • Short description
    Protein synthesis inhibitor. Cell culture selection antibiotic.
  • Biological description

    Aminonucleoside antibiotic.which disrupts peptide transfer on ribosomes on both prokaryotic and eukaryotic ribosomes to cause premature chain termination during translation.

    Inhibits protein transport of into the mitochondria.

    Also induces apoptosis and shows antineoplastic and antibacterial activity.

    Widely used as a selection antibiotic in cell culture. Puromycin allows the selection of cells that contain the puromycin N-acetyl-transferase gene (PAC) resistance gene.

  • Biological action
    Antibiotic
  • Applications
    Cell Culture, Selection Agent
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    3'-[?-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
  • Molecular Weight
    544.43
  • Molecular Formula
    C22H29N7O5.2HCl
  • CAS Number
    58-58-2
  • PubChem identifier
    443311
  • SMILES
    CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
  • InChiKey
    RXWNCPJZOCPEPQ-VJWOANPKSA-N
  • MDL number
    MFCD00012691
  • Appearance
    White to off-white

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    Soluble in DMSO (100 mM) and water (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Puromycin dihydrochloride

  • Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction.

    Price and Verner (1993) Biochim Biophys Acta. 1150(1) : 89-97
    PubMedID: 8334141
  • Complexes between nascent polypeptides and their molecular chaperones in the cytosol of mammalian cells.

    Eggers et al (1997) Mol Biol Cell 8(8) : 1559-73
    PubMedID: 9285825
  • Dipeptidyl arylamidase II of the pituitary. Properties of lysylalanyl-beta-naphthylamide hydrolysis: inhibition by cations, distribution in tissues, and subcellular localization.

    McDonald et al (1968) J Biol Chem 243(8) : 2028-37
    PubMedID: 5646493
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