Product overview

Name Pyroxamide
Alternative names Suberoyl-3-aminopyridineamide hydroxamic acid
Purity >98%
Description Potent HDAC inhibitor
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Biological Data

Biological description Potent histone deacetylase (HDAC) inhibitor (ID50 = 100 nM for HDAC1). Increases p21/WAF expression and shows growth inhibitory actions in cancer cells.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name N-Hydroxy-N'-3-pyridinyloctanediamid e
Molecular Weight 265.31
Chemical structure Pyroxamide  [382180-17-8] Chemical Structure
Molecular Formula C13H19N3O3
CAS Number 382180-17-8
PubChem identifier 4996
SMILES O=C(CCCCCCC(NO)=O)NC1=CC=CN=C1
InChiKey PTJGLFIIZFVFJV-UHFFFAOYSA-N

References for Pyroxamide

References are publications that support the biological activity of the product
  • Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.

    Kutko MC et al (2003) Clin Cancer Res 9(15) : 5749-55.
  • Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase.

    Butler LM et al (2001) Clin Cancer Res 7(4) : 962-70.

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