Product overview

Name Q-VD-OPh
Purity >95%
Description Cell permeable, irreversible and non-toxic pan-caspase inhibitor
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Biological Data

Biological description

Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies.

Negative control also available.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone
Molecular Weight 513.5
Chemical structure Q-VD-OPh [1135695-98-5 (anhydrous)] Chemical Structure
CAS Number 1135695-98-5 (anhydrous)
InChiKey OOBJCYKITXPCNS-AKRCKQFNSA-N
Appearance White solid