Quinolinic acid

(HB0544)

Product overview

  • Name
    Quinolinic acid
  • Short description
    Endogenous NMDA receptor agonist
  • Biological description
    Endogenous NMDA receptor agonist. Shows no activation at GluN1 and GluN2C subunit containing receptors. Displays neurotoxin and pro-inflammatory properties.
  • Biological action
    Agonist
  • Our products in action

Properties

  • Chemical name
    Pyridine-2,3-dicarboxylic acid
  • Molecular Weight
    167.12
  • Chemical structure
    Quinolinic acid  [89-00-9]
  • Molecular Formula
    C7H5NO4
  • CAS Number
    89-00-9

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in NaOH(aq) (50mM, 1eq. NaOH)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Quinolinic acid

  • Quinolinic acid, the inescapable neurotoxin.

    Guillemin GJ (2012) FEBS J 279(8) : 1356-65.
    PubMedID: 22248144
  • The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.

    de Carvalho LP et al (1996) Neurochem Int 28(4) : 445-52.
    PubMedID: 8740453
  • Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.

    Heyes MP et al (1992) Brain 115 ( Pt 5) : 1249-73.
    PubMedID: 1422788
  • Quinolinic acid: an endogenous neurotoxin with multiple targets.

    Lugo-Huitrón R et al (2013) Oxid Med Cell Longev 2013 : 104024
    PubMedID: 24089628