QX 314 chloride

(HB1030)

Product overview

  • Name
    QX 314 chloride
  • Short description
    Membrane impermeable Na+ channel blocker
  • Biological description

    Membrane impermeable Na+ channel blocker. A quaternary derivative of lidocaine. Reduces amplitude of high threshold Ca2+ currents in CA1 neurons. Displays anesthetic properties. Active in vivo. QX 314 bromide also available.

  • Alternative names
    N-Ethyllidocaine chloride
  • Biological action
    Blocker
  • Purity
    >98%
  • Our products in action

Images

Properties

  • Chemical name
    N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
  • Molecular Weight
    298.85
  • Chemical structure
    QX 314 chloride  [1265634]
  • Molecular Formula
    C16H27N2OCl
  • CAS Number
    5369-03-9
  • PubChem identifier
    21462
  • SMILES
    CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Cl-]
  • Source
    Synthetic
  • InChi
    InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
  • InChiKey
    LLPPOMUAOGMYQI-UHFFFAOYSA-N
  • MDL number
    MFCD01669894
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for QX 314 chloride

  • Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells.

    Colling SB et al (1994) Neurosci Lett 172(1-2) : 73-96.
    PubMedID: 8084540
  • Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.

    Talbot MJ et al (1996) J Neurophysiol 76(3) : 2120-4.
    PubMedID: 8890325
The following papers have cited the use of QX 314 chloride (HB1030) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

    Valentinova and Mameli(2016) Cell Rep 16(9) : 2298-307
    PubMedID: 27545888

Reviews & Product Guides

Reviews

  • Verified customer, University of Kiel

    It works as it should