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Data

Product overview

  • Name
    QX 314 chloride
  • Short description
    Membrane impermeable Na+ channel blocker
  • Biological description

    Membrane impermeable Na+ channel blocker. A quaternary derivative of lidocaine. Displays anesthetic properties. Active in vivo. QX 314 bromide also available.

  • Alternative names
    N-Ethyllidocaine chloride
  • Biological action
    Blocker
  • Purity
    >98%
  • Citations

Images

Properties

  • Chemical name
    N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
  • Molecular Weight
    298.85
  • Chemical structure
    QX 314 chloride  [1265634]
  • Molecular Formula
    C16H27N2OCl
  • CAS Number
    09/03/5369
  • PubChem identifier
    21462
  • SMILES
    CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Cl-]
  • Source
    Synthetic
  • InChi
    InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
  • InChiKey
    LLPPOMUAOGMYQI-UHFFFAOYSA-N
  • MDL number
    MFCD01669894
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for QX 314 chloride

  • Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells.

    Colling SB et al (1994) Neurosci Lett 172(1-2) : 73-96.
    PubMedID: 8084540
  • Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.

    Talbot MJ et al (1996) J Neurophysiol 76(3) : 2120-4.
    PubMedID: 8890325
Our products in action
The following papers have cited the use of QX 314 chloride (HB1030) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

    Valentinova and Mameli(2016) Cell Rep 16(9) : 2298-307
    PubMedID: 27545888
  • Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms.

    Tchenio et al(2017) Nat Commun 8(1) : 1135
    PubMedID: 29074844
  • The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

    Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646
    PubMedID: 30590038
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Reviews & Product Guides

Reviews

  • Verified customer

    QX 314 Chloride blocker. We routinely use this sodium channel blocker in our lab. We bought it from another supplier and again Hello Bio's formulation worked as expected for less. Thanks!
  • Verified customer

    Reasonable price and it works as it should.
  • Verified customer, University of Kiel

    It works as it should