QX 314 chloride


Product overview

  • Name
    QX 314 chloride
  • Short description
    Membrane impermeable Na+ channel blocker
  • Biological description

    Membrane impermeable Na+ channel blocker. A quaternary derivative of lidocaine. Reduces amplitude of high threshold Ca2+ currents in CA1 neurons. Displays anesthetic properties. Active in vivo. QX 314 bromide also available.

  • Alternative names
    N-Ethyllidocaine chloride
  • Biological action
  • Purity
  • Citations



  • Chemical name
    N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
  • Molecular Weight
  • Chemical structure
    QX 314 chloride  [1265634]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for QX 314 chloride

  • Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells.

    Colling SB et al (1994) Neurosci Lett 172(1-2) : 73-96.
    PubMedID: 8084540
  • Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.

    Talbot MJ et al (1996) J Neurophysiol 76(3) : 2120-4.
    PubMedID: 8890325
The following papers have cited the use of QX 314 chloride (HB1030) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

    Valentinova and Mameli(2016) Cell Rep 16(9) : 2298-307
    PubMedID: 27545888
  • Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms.

    Tchenio et al(2017) Nat Commun 8(1) : 1135
    PubMedID: 29074844

Reviews & Product Guides


  • Verified customer, University of Kiel

    It works as it should