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Raseglurant (ADX 10059 hydrochloride)

(HB1557)
Data

Product overview

  • Name
    Raseglurant (ADX 10059 hydrochloride)
  • Short description
    mGlu5 negative allosteric modulator
  • Biological description
    mGlu5 receptor negative allosteric modulator. Potential anti-reflux and anti-migraine actions.
  • Biological action
    NAM
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride
  • Molecular Weight
    276.74
  • Chemical structure
    Raseglurant [757949-98-7]
  • Molecular Formula
    C15H13N2F · HCl
  • CAS Number
    757949-98-7
  • PubChem identifier
    18454771
  • SMILES
    CC1=CC(=NC(=C1N)C#CC2=CC(=CC=C2)F)C.Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C15H13FN2.ClH/c1-10-8-11(2)18-14(15(10)17)7-6-12-4-3-5-13(16)9-12;/h3-5,8-9H,17H2,1-2H3;1H
  • InChiKey
    BDXXMGYKLQZXOU-UHFFFAOYSA-N
  • Appearance
    Yellow solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for Raseglurant (ADX 10059 hydrochloride)

  • A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease.

    Keywood C et al (2009) Gut 58(9) : 1192-9.
    PubMedID: 19460767
  • 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.

    Weiss JM et al (2011) Bioorg Med Chem Lett 21(16) : 4891-9.
    PubMedID: 21757343
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