Repaglinide

(HB1106)

Product overview

  • Name
    Repaglinide
  • Short description
    Potent SUR1 / Kir6.2 channel blocker
  • Biological description
    Potent SUR1 / Kir6.2 channel blocker (KD = 0.42 nM). Also binds to sulphonylurea receptor 1 (SUR1) alone (KD = 59 nM). Displays antidiabetic properties.
  • Biological action
    Blocker
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benz oic acid
  • Molecular Weight
    452.59
  • Chemical structure
    Repaglinide  [135062-02-1]
  • Molecular Formula
    C27H36N2O4
  • CAS Number
    135062-02-1

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Repaglinide

  • Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.

    Hansen AM et al (2005) Br J Pharmacol 144(4) : 551-7.
    PubMedID: 15678092
  • Antioxidative and anti-inflammatory effects of repaglinide in plasma of diabetic animals.

    Gumieniczek A et al (2005) Pharmacol Res 52(2) : 162-6.
    PubMedID: 15967382
  • Novel anti-inflammatory effects of repaglinide in rodent models of inflammation.

    Tung D et al (2011) Pharmacology 88(5-6) : 295-301.
    PubMedID: 22086064

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