Product overview

Name Repaglinide
Alternative names AG-EE 623ZW
Purity >99%
Description Potent SUR1 / Kir6.2 channel blocker
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Biological Data

Biological description Potent SUR1 / Kir6.2 channel blocker (KD = 0.42 nM). Also binds to sulphonylurea receptor 1 (SUR1) alone (KD = 59 nM). Displays antidiabetic properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benz oic acid
Molecular Weight 452.59
Chemical structure Repaglinide  [135062-02-1] Chemical Structure
Molecular Formula C27H36N2O4
CAS Number 135062-02-1
PubChem identifier 65981
SMILES O=C(CC3=CC(OCC)=C(C(O)=O)C=C3)N[C@@H](CC(C)C)C1=CC=CC=C1N2CCCCC2
InChiKey FAEKWTJYAYMJKF-QHCPKHFHSA-N

References for Repaglinide

References are publications that support the biological activity of the product
  • Novel anti-inflammatory effects of repaglinide in rodent models of inflammation.

    Tung D et al (2011) Pharmacology 88(5-6) : 295-301.
  • Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.

    Hansen AM et al (2005) Br J Pharmacol 144(4) : 551-7.
  • Antioxidative and anti-inflammatory effects of repaglinide in plasma of diabetic animals.

    Gumieniczek A et al (2005) Pharmacol Res 52(2) : 162-6.

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