Product overview

Name RepSox
Alternative names E-616452, SJN 2511, ALK5 Inhibitor II
Purity >99%
Description Potent, selective TGF-βRI inhibitor. Enhances cellular reprogramming efficiency.
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Biological Data

Biological description

Potent, selective TGF-βRI/ALK5 inhibitor (IC50 values are 4 and 23 nM TGF-βRI autophosphorylation and binding respectively. Selective for TGF-βRI/ compared to a range of kinases (p38 MAPK, GSK-3, JNK1).

Enhances cellular reprogramming efficiency by replacing the Sox2 factor by inducing Nanog expression

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Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Chemical name 2-(3-(6-Methylpyridine-2-yl)-1H-pyr azol-4-yl)-1,5-naphthyridine
Molecular Weight 287.32
Chemical structure RepSox | E-616452, SJN 2511, ALK5 Inhibitor II  [446859-33-2] Chemical Structure
Molecular Formula C17H13N5
CAS Number 446859-33-2
PubChem identifier 449054
SMILES CC1=NC(C2=NNC=C2C4=NC3=CC=CN=C3C=C4)=CC=C1
InChiKey LBPKYPYHDKKRFS-UHFFFAOYSA-N