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Data

Product overview

  • Name
    Reserpine
  • Short description
    Vesicular monoamine re-uptake blocker
  • Biological description
    Vesicular monoamine re-uptake blocker. Irreversibly binds VMAT2 to deplete synaptic monoamines. Produces depression-like effects and shows antipsychotic and antihypertensive effects.
  • Biological action
    Blocker
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (3β,16β,17α,18β,20α)-11,17-Dimethoxy-18- [(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxyl ic acid methyl ester
  • Molecular Weight
    608.68
  • Chemical structure
    Reserpine  [50-55-5]
  • Molecular Formula
    C33H40N2O9
  • CAS Number
    50-55-5
  • PubChem identifier
    5770
  • SMILES
    CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
  • InChi
    InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
  • InChiKey
    QEVHRUUCFGRFIF-MDEJGZGSSA-N
  • MDL number
    MFCD00005091

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (10 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Reserpine

  • Radioligands of the vesicular monoamine transporter and their use as markers of monoamine storage vesicles.

    Henry JP et al (1989) Biochem Pharmacol 38(15) : 2395-404.
    PubMedID: 2667522
  • Reserpine binding to a vesicular amine transporter expressed in Chinese hamster ovary fibroblasts.

    Schuldiner S et al (1993) J Biol Chem 268(1) : 29-34.
    PubMedID: 8416935
  • Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine: behavioral and neurochemical studies in the rat.

    Antkiewicz-Michaluk L et al (2014) Neurotox Res 26(1) : 85-98.
    PubMedID: 24407488
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