Resiniferatoxin

(HB1185)

Product overview

  • Name
    Resiniferatoxin
  • Short description
    Potent TRPV1 channel agonist
  • Biological description
    Capsaicin analogue. Potent TRPV1 channel agonist (Ki = 42.5 pM). Shows actions against neuropathic pain and inhibits inflammatory hyperalgesia. Shows musculoskeletal hyperalgesic effects.
  • Biological action
    Agonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneacetate
  • Molecular Weight
    628.72
  • Chemical structure
    Resiniferatoxin  [57444-62-9]
  • Molecular Formula
    C37H40O9
  • CAS Number
    57444-62-9

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Resiniferatoxin

  • Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes.

    Acs G et al (1996) Brain Res Mol Brain Res 35(1-2) : 173-82.
    PubMedID: 8717353
  • Resiniferatoxin (RTX) causes a uniquely protracted musculoskeletal hyperalgesia in mice by activation of TRPV1 receptors.

    Abdelhamid RE et al (2013) J Pain 14(12) : 1629-41.
    PubMedID: 24188863
  • Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia.

    Neubert JK et al (2008) Mol Pain 4 : 3
    PubMedID: 18199335

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