Product overview

  • Name
    RG 108
  • Short description
    Non-nucleoside DNA methyltransferase inhibitor. Enhances iPSC generation efficiency.
  • Biological description
    Non-nucleoside DNA methyltransferase (DNMT) inhibitor (IC50 = 115 nM). Binds at the active site. Causes hypomethylation and reactivates tumor suppressor genes. Shows growth inhibiting and pro-apoptotic anti-cancer actions. Also enhances iPSC generation efficiency.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N-Phthalyl-L-tryptophan
  • Molecular Weight
    334.33
  • Chemical structure
    RG 108  [48208-26-0]
  • Molecular Formula
    C19H14N2O4
  • CAS Number
    48208-26-0

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for RG 108

  • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

    Brueckner B et al (2005) Cancer Res 65(14) : 6305-11.
    PubMedID: 16024632
  • Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells.

    Graã?a I et al (2014) Curr Pharm Des 20(11) : 1803-11.
    PubMedID: 23888969
  • Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

    Stresemann C et al (2006) Cancer Res 66(5) : 2794-800.
    PubMedID: 16510601