Riluzole hydrochloride

(HB0548)

Product overview

  • Name
    Riluzole hydrochloride
  • Short description
    Na+ channel blocker / glutamate inhibitor
  • Biological description
    Na+ channel blocker. Increases glutamate uptake and inhibits glutamate release. Also inhibits GABA uptake. Non-competitive NMDA receptor and Protein kinase C (PKC) inhibitor. Shows neuroprotective, anxiolytic, anticonvulsant and anesthetic actions. Shows actions against motorneuron disease.
  • Alternative names
    PK 26124
  • Biological action
    Blocker
  • Purity
    >98%
  • Citations

Images

Properties

  • Chemical name
    2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
  • Molecular Weight
    270.66
  • Chemical structure
    Riluzole hydrochloride  [850608-87-6]
  • Molecular Formula
    C8H5F3N2OS.HCl
  • CAS Number
    850608-87-6
  • PubChem identifier
    6419992
  • SMILES
    C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N.Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C8H5F3N2OS.ClH/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5;/h1-3H,(H2,12,13);1H
  • InChiKey
    QEAOELIJQRYJJS-UHFFFAOYSA-N
  • MDL number
    MFCD00210213
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100mM, gentle warming) and in water (10mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Riluzole hydrochloride

  • Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia.

    Wu Y et al (2014) Neuroscience 265 : 302-12.
    PubMedID: 24508749
  • Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.

    Fumagalli E et al (2008) Eur J Pharmacol 578(2-3) : 171-6.
    PubMedID: 18036519
  • Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro.

    Lamanauskas N et al (2008) Eur J Neurosci 27(10) : 2501-14.
    PubMedID: 18445055
  • Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines.

    Sugiyama A et al (2012) Neuropharmacology 62(8) : 2489-98.
    PubMedID: 22377384