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Data

Product overview

  • Name
    Riluzole
  • Short description
    Na+ channel blocker / glutamate inhibitor
  • Biological description
    Na+ channel blocker. Increases glutamate uptake and inhibits glutamate release. Also inhibits GABA uptake. Non-competitive NMDA receptor and Protein kinase C (PKC) inhibitor. Shows neuroprotective, anxiolytic, anticonvulsant and anesthetic actions. Shows actions against motorneuron disease.
  • Alternative names
    PK 26124
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Customer comments

    Great quality by half the price of other suppliers. We have been using riluzole from regular suppliers for many years. Now, we have tested Riluzole from Hello Bio and this has worked fantastic. Compound activity is comparable to the previous one, but the price is almost half of it. Also, the user experience working with them is easy and fast. I definitely recommend this compound. Verified customer, University of Vigo

  • Citations

Properties

  • Chemical name
    2-Amino-6-(trifluoromethoxy)benzothiazole
  • Molecular Weight
    234.2
  • Chemical structure
    Riluzole [1744-22-5]
  • Molecular Formula
    C8H5F3N2OS
  • CAS Number
    1744-22-5
  • PubChem identifier
    5070
  • SMILES
    C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
  • InChi
    InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
  • InChiKey
    FTALBRSUTCGOEG-UHFFFAOYSA-N
  • MDL number
    MFCD00210213

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Riluzole

  • Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines.

    Sugiyama A et al (2012) Neuropharmacology 62(8) : 2489-98.
    PubMedID: 22377384
  • Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro.

    Lamanauskas N et al (2008) Eur J Neurosci 27(10) : 2501-14.
    PubMedID: 18445055
  • Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.

    Fumagalli E et al (2008) Eur J Pharmacol 578(2-3) : 171-6.
    PubMedID: 18036519
  • Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia.

    Wu Y et al (2014) Neuroscience 265 : 302-12.
    PubMedID: 24508749
Our products in action
The following papers have cited the use of Riluzole (HB6093) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons

    Fernández-Fernández D, Cadaveira-Mosquera A, Rueda-Ruzafa L, Herrera-Pérez S, Veale EL, Reboreda A, Mathie A, Lamas JA.(2018) Plos ONE 13(6) : e0199282
    PubMedID: 29928032
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Reviews

  • Verified customer, University of Vigo

    Great quality by half the price of other suppliers. We have been using riluzole from regular suppliers for many years. Now, we have tested Riluzole from Hello Bio and this has worked fantastic. Compound activity is comparable to the previous one, but the price is almost half of it. Also, the user experience working with them is easy and fast. I definitely recommend this compound.