Product overview

  • Name
    RN 1734
  • Short description
    TRPV4 channel antagonist
  • Biological description
    TRPV4 channel antagonist (IC50 values are 2.3, 3.2 and 5.9 µM for hTRPV4, rTRPV4 and mTRPV4). Exhibits higher selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8 channels (IC50 values = >30 µM). Also blocks ATP-sensitive K+ channels.
  • Biological action
    Antagonist
  • Our products in action

Properties

  • Chemical name
    2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide
  • Molecular Weight
    353.31
  • Chemical structure
    RN 1734  [946387-07-1]
  • Molecular Formula
    C14H22Cl2N2O2S
  • CAS Number
    946387-07-1
  • PubChem identifier
    3601086
  • SMILES
    CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl
  • InChi
    InChI=1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3
  • InChiKey
    IHYZMEAZAIFMTN-UHFFFAOYSA-N
  • MDL number
    MFCD00129453
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for RN 1734

  • Identification and characterization of novel TRPV4 modulators.

    Vincent F et al (2009) Biochem Biophys Res Commun 389(3) : 490-4.
    PubMedID: 19737537
  • Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone.

    Bagher P et al (2012) Proc Natl Acad Sci U S A 109(44) : 18174-9.
    PubMedID: 23071308

Reviews & Product Guides