RN 1734

(HB1196)

Order: HB1196

Pack	Price	Qty
5mg	$41
25mg	$169

(HB1196)

Data

Product overview

Name
RN 1734
Short description
TRPV4 channel antagonist
Biological description
TRPV4 channel antagonist (IC₅₀ values are 2.3, 3.2 and 5.9 µM for hTRPV4, rTRPV4 and mTRPV4). Exhibits higher selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8 channels (IC₅₀ values = >30 µM). Also blocks ATP-sensitive K⁺ channels.
Biological action
Antagonist
Citations
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Chemical name
2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide
Molecular Weight
353.31
Chemical structure
Molecular Formula
C₁₄H₂₂Cl₂N₂O₂S
CAS Number
946387-07-1
PubChem identifier
3601086
SMILES
CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl
InChi
InChI=1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3
InChiKey
IHYZMEAZAIFMTN-UHFFFAOYSA-N
MDL number
MFCD00129453
Appearance
White solid

Storage instructions
+4°C
Solubility overview
Soluble in DMSO (100mM) and in ethanol (50mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Identification and characterization of novel TRPV4 modulators.

Vincent F et al (2009) Biochem Biophys Res Commun 389(3) : 490-4.
PubMedID: 19737537
Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone.

Bagher P et al (2012) Proc Natl Acad Sci U S A 109(44) : 18174-9.
PubMedID: 23071308

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