RN 1747

(HB1186)

Product overview

  • Name
    RN 1747
  • Short description
    Selective TRPV4 agonist
  • Biological description
    Selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 µM for human, mouse and rat TRPV4 respectively). Displays selectivity for TRPV4 over TRPM8, TRPV1 and TRPV3. Also TRPM8 antagonist (IC50 = 4.0 µM).
  • Biological action
    Agonist
  • Citations

Properties

  • Chemical name
    1-(4-Chloro-2-nitrophenyl)sulfonyl- 4-benzylpiperazine
  • Molecular Weight
    395.87
  • Chemical structure
    RN 1747  [1024448-59-6]
  • Molecular Formula
    C17H18ClN3O4S
  • CAS Number
    1024448-59-6
  • PubChem identifier
    5068295
  • SMILES
    C1CN(CCN1CC2=CC=CC=C2)S(=O)(=O)C3=C(C=C(C=C3)Cl)[N+](=O)[O-]
  • InChi
    InChI=1S/C17H18ClN3O4S/c18-15-6-7-17(16(12-15)21(22)23)26(24,25)20-10-8-19(9-11-20)13-14-4-2-1-3-5-14/h1-7,12H,8-11,13H2
  • InChiKey
    ZNLVYSJQUMALEO-UHFFFAOYSA-N
  • MDL number
    MFCD04154169

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for RN 1747

  • Identification and characterization of novel TRPV4 modulators.

    Vincent F et al (2009) Biochem Biophys Res Commun 389(3) : 490-4.
    PubMedID: 19737537

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