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Ro 32-0432 hydrochloride

(HB4820)
Data

Product overview

  • Name
    Ro 32-0432 hydrochloride
  • Short description
    Potent, selective PKC inhibitor. GRK inhibitor.
  • Biological description
    Potent and selective protein kinase C (PKC) inhibitor (IC50 = 21 nM). Selective for PKC-α over PKC-βI, PKC-βII, PKC-γ and PKC-ε (IC50 values are 9, 28, 31, 37 and 108 nM respectively). Also a GRK inhibitor (IC50 values are 29, 3.6 and 16μM respectively). Inhibits T cell proliferation, interleukin-2 (IL-2) secretion and IL-2 receptor expression. Cell permeable.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Molecular Weight
    452.5
  • Chemical structure
    Ro 32-0432 hydrochloride [1145333-02-4]
  • Molecular Formula
    C28H28N4O2.HCl
  • CAS Number
    145333-02-4
  • InChiKey
    HSPRASOZRZDELU-UHFFFAOYSA-N

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    Soluble in DMSO or methanol.
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
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