Ro-32-0432

(HB0560)

Product overview

  • Name
    Ro-32-0432
  • Short description
    Potent, selective PKC inhibitor
  • Biological description
    Potent and selective protein kinase C inhibitor (IC50 values are 21, 9, 28, 31, 37 and 108 nM for PKC, PKC-α, PKC-β1, PKC-β2, PKC-γ and PKC-ε respectively). Displays 10 -and 4- fold selectivity for PKC-α and PKC-β1 over PKC-ε respectively. Also a G protein-coupled receptor kinase 5 inhibitor. Cell permeable. Displays anti-inflammatory properties.
  • Biological action
    Inhibitor
  • Our products in action

Properties

  • Chemical name
    Bisindolylmaleimide XI hydrochloride
  • Molecular Weight
    489.01
  • Molecular Formula
    C28H28N4O2 HCl
  • CAS Number
    151342-35-7
  • PubChem identifier
    11605551
  • SMILES
    CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN(C)C.Cl

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ro-32-0432

  • Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.

    Birchall AM et al (1994) J Pharmacol Exp Ther 268(2) : 922-9.
    PubMedID: 8114006
  • Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.

    Wilkinson SE et al (1993) Biochem J 294 ( Pt 2) : 335-7.
    PubMedID: 8373348
  • Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.

    Singh TG et al (2013) Naunyn Schmiedebergs Arch Pharmacol 386(3) : 197-204.
    PubMedID: 23274455

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