Ro 61-8048

(HB0556)

Product overview

  • Name
    Ro 61-8048
  • Short description
    Potent, competitive kynurenine 3-hydroxylase inhibitor
  • Biological description
    Potent and competitive kynurenine 3-hydroxylase inhibitor (IC50 = 37 nM). Blocks the effects of cannabinoid CB1 agonists. Displays antidystonic, neuroprotective and anticonvulsive properties. Blood brain barrier permeable.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
  • Molecular Weight
    421.45
  • Chemical structure
    Ro 61-8048  [199666-03-0]
  • Molecular Formula
    C17H15N3O6S2
  • CAS Number
    199666-03-0

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (10mM)

References for Ro 61-8048

  • Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.

    Röver S et al (1997) J Med Chem 40(26) : 4378-85.
    PubMedID: 9435907
  • The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.

    Richter A et al (2003) Eur J Pharmacol 478(1) : 47-52.
    PubMedID: 14555184
  • Kynurenines in the mammalian brain: when physiology meets pathology.

    Schwarcz R et al (2012) Nat Rev Neurosci 13(7) : 465-77.
    PubMedID: 22678511

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