Rottlerin

(HB0561)

Product overview

  • Name
    Rottlerin
  • Short description
    PKC inhibitor
  • Biological description
    Protein kinase C inhibitor (IC50 = 3-6 µM for PKC-δ). Inhibits cAM-kinase III, PRAK (IC50 = 1.9 µM) and MAPKAP-K2 (IC50 = 5.4 µM). Novel lipoprotein receptor-related protein-6 (LRP6) inhibitor. Also suppresses Wnt/β-catenin and mTORC1 signalling. Displays cell growth suppressing, apoptosis inducing and anti-angiogenesis properties.
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
  • Molecular Weight
    516.55
  • Chemical structure
    Rottlerin  [82-08-6]
  • Molecular Formula
    C30H28O8
  • CAS Number
    82-08-6
  • PubChem identifier
    5281847
  • SMILES
    CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)/C=C/C4=CC=CC=C4)OC(C=C3)(C)C)O)O

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in ethanol (2mM, gentle warming) or DMSO (20mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Rottlerin

  • Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.

    Lu W et al (2014) Cell Signal 26(6) : 1303-9.
    PubMedID: 24607787
  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.
    PubMedID: 10998351
  • Rottlerin, a novel protein kinase inhibitor.

    Gschwendt M et al (1994) Biochem Biophys Res Commun 199(1) : 93-8.
    PubMedID: 8123051
  • Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method.

    Lu QY et al (2013) J Chromatogr Sep Tech 4(1) :
    PubMedID: 24482742

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