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Biological Data

Biological description Protein kinase C inhibitor (IC50 = 3-6 µM for PKC-δ). Inhibits cAM-kinase III, PRAK (IC50 = 1.9 µM) and MAPKAP-K2 (IC50 = 5.4 µM). Novel lipoprotein receptor-related protein-6 (LRP6) inhibitor. Also suppresses Wnt/β-catenin and mTORC1 signalling. Displays cell growth suppressing, apoptosis inducing and anti-angiogenesis properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in ethanol (2mM, gentle warming) or DMSO (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Molecular Weight 516.55
Chemical structure Rottlerin  [82-08-6] Chemical Structure
Molecular Formula C30H28O8
CAS Number 82-08-6
PubChem identifier 5281847
SMILES CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)/C=C/C4=CC=CC=C4)OC(C=C3)(C)C)O)O
InChiKey DEZFNHCVIZBHBI-ZHACJKMWSA-N

References for Rottlerin

References are publications that support the biological activity of the product
  • Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.

    Lu W et al (2014) Cell Signal 26(6) : 1303-9.
  • Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method.

    Lu QY et al (2013) J Chromatogr Sep Tech 4(1) :
  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.
  • Rottlerin, a novel protein kinase inhibitor.

    Gschwendt M et al (1994) Biochem Biophys Res Commun 199(1) : 93-8.

4 Item(s)