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RS-1

(HB5647)
Data

Product overview

  • Name
    RS-1
  • Short description
    hRAD51 stimulator. Enhances CRISPR genome editing efficiency.
  • Biological description

    Stimulator of the homologous recombination protein hRAD51. Enhances the DNA binding and homologous recombination activities of hRAD51.


    Improves efficiency of HDR (homology-directed repair) 3- to 6-fold (depending on locus and transfection method).

    Also enhances Cas9- and TALEN-mediated knock in efficiency in vitro and in vivo. Increases knock-in efficiency in vitro by 2- to 5-fold at different loci and achieves multi-fold improvement in vivo.

    Additionally promotes significant anti-tumor responses.

  • Alternative names
    RS1, RAD51-Stimulatory Compound-1,
  • Biological action
    Activator
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
  • Molecular Weight
    524.2
  • Chemical structure
    RS-1 [312756-74-4]
  • Molecular Formula
    C20H16N2O3SBr2
  • CAS Number
    312756-74-4
  • PubChem identifier
    1039737
  • SMILES
    C1=CC=C(C=C1)CNS(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC=C(C=C3)Br)Br
  • Source
    Synthetic
  • InChi
    InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
  • InChiKey
    SWKAVEUTKGKHSR-UHFFFAOYSA-N
  • MDL number
    MFCD00348720
  • Appearance
    Brown solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for RS-1

  • RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency.

    Song et al (2016) Nat Commun 28 : 7-10548
    PubMedID: 26817820
  • A chemical compound that stimulates the human homologous recombination protein RAD51.

    Jayathilaka et al (2008) Proc Natl Acad Sci U S A. 105(41) : 15848-53
    PubMedID: 18840682
  • The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.

    Mason et al (2014) Cancer Res 74(13) : 3546-55
    PubMedID: 24753542
  • Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing.

    Pinder et al (2015) Nucleic Acids Res. 43(19) : 9379-92
    PubMedID: 26429972
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