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(R,S)-MCPG sodium salt

(HB0038)
Data

Product overview

  • Name
    (R,S)-MCPG sodium salt
  • Short description
    Water soluble, non-selective group I and II mGluR antagonist
  • Biological description

    Water soluble non-selective group I and II mGluR antagonist.

    Also competitive antagonist of ACPD sensitive receptors.

    Shows no effect on locomotor activity.

    (R,S)-MCPG and (S)-MCPG sodium salt also available. (S)-MCPG also available.

  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (RS)-α-Methyl-4-carboxyphenylglycine disodium salt
  • Molecular Weight
    253.16
  • Chemical structure
    (R,S)-MCPG sodium salt  [1303994-09-3]
  • Molecular Formula
    C10H9NNa2O4
  • CAS Number
    1303994-09-3
  • SMILES
    NC(C)(C(=O)O[Na])c1ccc(cc1)C(=O)O
  • Source
    Synthetic
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (R,S)-MCPG sodium salt

  • The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats.

    Kim JH et al (1998) Neuropharmacology 37(2) : 189-97.
    PubMedID: 9680243
  • MCPG antagonizes metabotropic glutamate receptors but not long-term potentiation in the hippocampus.

    Manzoni OJ et al (1994) Eur J Neurosci 6(6) : 1050-4.
    PubMedID: 7952274
  • Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.

    Eaton SA et al (1993) Eur J Pharmacol 244(2) : 195-7.
    PubMedID: 8381746
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