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Biological Data

Biological description

Non-selective group I and II mGluR antagonist.

Also competitive antagonist of ACPD sensitive receptors.

Shows no effect on locomotor activity.

Water soluble (R,S)-MCPG sodium salt and (S)-MCPG sodium salt also available. (S)-MCPG also available.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in 0.1M NaOH (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (RS)-α-Methyl-4-carboxyphenylglycine
Molecular Weight 209.2
Chemical structure (RS)-MCPG  [146669-29-6] Chemical Structure
Molecular Formula C10H11NO4
CAS Number 146669-29-6
PubChem identifier 1222
SMILES CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N
Source Synthetic
InChi InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
InChiKey DNCAZYRLRMTVSF-UHFFFAOYSA-N
MDL number MFCD00210205
Appearance White solid

References for (RS)-MCPG

References are publications that support the biological activity of the product
  • The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats.

    Kim JH et al (1998) Neuropharmacology 37(2) : 189-97.
  • MCPG antagonizes metabotropic glutamate receptors but not long-term potentiation in the hippocampus.

    Manzoni OJ et al (1994) Eur J Neurosci 6(6) : 1050-4.
  • Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.

    Eaton SA et al (1993) Eur J Pharmacol 244(2) : 195-7.

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