Product overview

  • Name
    (R,S)-CHPG
  • Short description
    Selective mGlu5 agonist
  • Biological description

    Selective mGlu5 receptor agonist which shows no activity at mGlu1. Potentiates NMDA-induced depolarizations in rat hippocampal slices. Active in vivo. Water soluble CHPG sodium salt also available.

  • Alternative names
    (R,S)-2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
  • Biological action
    Agonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (R,S)-2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
  • Molecular Weight
    201.61
  • Chemical structure
    (R,S)-CHPG  [170846-74-9]
  • Molecular Formula
    C8H8NO3Cl
  • CAS Number
    170846-74-9
  • PubChem identifier
    3645780
  • SMILES
    C1=CC(=C(C=C1O)C(C(=O)O)N)Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
  • InChiKey
    UNIDAFCQFPGYJJ-UHFFFAOYSA-N
  • MDL number
    MFCD01321059
  • Appearance
    Off-white solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in 0.1M NaOH (100 mM)

References for (R,S)-CHPG

  • (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.

    Doherty AJ et al (1997) Neuropharmacology 36(2) : 265-7.
    PubMedID: 9144665
  • Activation of mGluR5 attenuates NMDA-induced neurotoxicity through disruption of the NMDAR-PSD-95 complex and preservation of mitochondrial function in differentiated PC12 cells.

    Dai SH et al (2014) Int J Mol Sci 15(6) : 10892-907.
    PubMedID: 24941251
  • The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway.

    Chen T et al (2012) Int J Mol Med 29(4) : 630-6.
    PubMedID: 22211238
  • Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices.

    Fazal A et al (2003) J Neurochem 86(6) : 1346-58.
    PubMedID: 12950444