Ryanodine

(HB1320)

Product overview

  • Name
    Ryanodine
  • Short description
    Potent Ca2+ release inhibitor
  • Biological description
    Potent Ca2+ release inhibitor. Inhibits release from the cardiac and skeletal muscle sarcoplasmic reticulum (IC50 values are 2.8 and 10 nM respectively). Shows actions to slow arrhythmia development in heart failure.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS) -dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-tri methyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pent aleno[1,6-bc]furan-8-yl ester
  • Molecular Weight
    493.55
  • Chemical structure
    Ryanodine  [15662-33-6]
  • Molecular Formula
    C25H35NO9
  • CAS Number
    15662-33-6
  • PubChem identifier
    11317883
  • SMILES
    CC(C)[C@@]6(O)C(OC(=O)c1cccn1)[C@]2(O)[C@@]5(O)[C@@]34O[C@@](O)(C[C@@]2(C)[C@@]4(O)CC[C@H](C)[C@H]3O)[C@]56C
  • Source
    Extracted from ryania speciosa
  • InChi
    InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19+,20-,21-,22+,23+,24+,25+/m0/s1
  • InChiKey
    JJSYXNQGLHBRRK-SFEDZAPPSA-N

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in ethanol (10mM) and in DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ryanodine

  • The pharmacology of ryanodine and related compounds.

    Sutko JL et al (1997) Pharmacol Rev 49(1) : 53-98.
    PubMedID: 9085309
  • Effects of sarcolemmal Ca(2+) entry, ryanodine function, and kinase inhibitors on a rabbit model of heart failure.

    Kijtawornrat A et al (2010) Int Heart J 51(4) : 285-90.
    PubMedID: 20716847
  • Ryanodine modification of RyR1 retrogradely affects L-type Ca(2+) channel gating in skeletal muscle.

    Bannister RA et al (2009) J Muscle Res Cell Motil 30(5-6) : 217-23.
    PubMedID: 19802526

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