S-Isopropyl-ITU hydrobromide

(HB0583)

Product overview

  • Name
    S-Isopropyl-ITU hydrobromide
  • Short description
    Potent, competitive NOS inhibitor
  • Biological description
    Potent and competitive NOS inhibitor (Ki = 5.2 nM for mouse iNOS).
  • Biological action
    Inhibitor
  • Citations

Properties

  • Molecular Weight
    199.1
  • CAS Number
    4269-97-0
  • PubChem identifier
    9813062
  • SMILES
    CC(C)SC(=N)N.Br

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO or water
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for S-Isopropyl-ITU hydrobromide

  • Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity.

    Southan GJ et al (1995) Br J Pharmacol 114(2) : 510-6.
    PubMedID: 7533622
  • Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.

    Garvey EP et al (1994) J Biol Chem 269(43) : 26669-76.
    PubMedID: 7523409
  • Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.

    Li H et al (2000) J Inorg Biochem 81(3) : 133-9.
    PubMedID: 11051558

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