S-Isopropyl-ITU hydrobromide

(HB0583)
Technical documents: Datasheet

Product overview

Name S-Isopropyl-ITU hydrobromide
Description Potent, competitive NOS inhibitor
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Biological Data

Biological description Potent and competitive NOS inhibitor (Ki = 5.2 nM for mouse iNOS).

Solubility & Handling

Solubility overview Soluble in DMSO or water
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Molecular Weight 199.1
CAS Number 4269-97-0
PubChem identifier 9813062
SMILES CC(C)SC(=N)N.Br

References for S-Isopropyl-ITU hydrobromide

References are publications that support the biological activity of the product
  • Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.

    Li H et al (2000) J Inorg Biochem 81(3) : 133-9.
  • Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity.

    Southan GJ et al (1995) Br J Pharmacol 114(2) : 510-6.
  • Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.

    Garvey EP et al (1994) J Biol Chem 269(43) : 26669-76.

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