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(S)-MCPG sodium salt

(HB6112)
Data

Product overview

  • Name
    (S)-MCPG sodium salt
  • Short description
    Non-selective group I and II mGluR antagonist. Water soluble sodium salt.
  • Biological description

    Non-selective group I and II mGluR antagonist. Water soluble sodium salt.

    Active enantiomer of (R,S)-MCPG.


    Displays slight activity at mGlu8 receptor but none at mGlu4 receptor.

    Inhibits MF-LTP (mossy fiber long term potentiation) and blocks induction of LTP in CA1 of rat hippocampus.


    (S)-MCPG and (R,S)-MCPG sodium salt also available.

  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (S)-α-Methyl-4-carboxyphenylglycine sodium salt
  • Molecular Weight
    231.18
  • Chemical structure
    S-MCPG | Hello Bio
  • Molecular Formula
    C10H10NNaO4
  • CAS Number
    150145-89-4
  • Source
    Syntheitc
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (S)-MCPG sodium salt

  • Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).

    Bedingfield JS et al (1995) Br J Pharmacol 116(8) : 3323-9.
    PubMedID: 8719814
  • Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.

    Sekiyama N et al (1996) Br J Pharmacol 117(7) : 1493-503.
    PubMedID: 8730745
  • Pharmacological agents acting at subtypes of metabotropic glutamate receptors.

    Schoepp DD et al (1999) Neuropharmacology 38(10) : 1431-76.
    PubMedID: 10530808
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