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(S)-4-Carboxyphenylglycine

(HB0049)
Data

Product overview

  • Name
    (S)-4-Carboxyphenylglycine
  • Short description
    Competitive, selective group 1 mGlu antagonist
  • Biological description
    Competitive and selective group 1 mGluR antagonist. Shows selectivity for mGluR1a over mGluR5a/5b. Displays preventative vasospasm properties.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Molecular Weight
    195.17
  • Chemical structure
    (S)-4-Carboxyphenylglycine  [134052-73-6]
  • Molecular Formula
    C9H9NO4
  • CAS Number
    134052-73-6

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in NaOH(aq) (100mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (S)-4-Carboxyphenylglycine

  • Antagonist activity of alpha-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells.

    Doherty AJ et al (1999) Br J Pharmacol 126(1) : 205-10.
    PubMedID: 10051137
  • A glutamate receptor antagonist, S-4-carboxyphenylglycine (S-4-CPG), inhibits vasospasm after subarachnoid hemorrhage in haptoglobin 2-2 mice [corrected].

    Garzon-Muvdi T et al (2013) Neurosurgery 73(4) : 719-28
    PubMedID: 23842553
  • Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses.

    Brabet I et al (1995) Neuropharmacology 34(8) : 895-903.
    PubMedID: 8532171
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