Saclofen

(HB0963)

Product overview

  • Name
    Saclofen
  • Short description
    Selective, competitive GABAB receptor antagonist
  • Biological description
    Selective and competitive GABAB receptor antagonist. Inhibits baclofen binding (IC50 = 7.8 µM).
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
  • Molecular Weight
    249.72
  • Chemical structure
    Saclofen  [125464-42-8]
  • Molecular Formula
    C9H12ClNO3S
  • CAS Number
    125464-42-8
  • PubChem identifier
    122150
  • SMILES
    C1=CC(=CC=C1C(CN)CS(=O)(=O)O)Cl
  • InChi
    InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
  • InChiKey
    JYLNVJYYQQXNEK-UHFFFAOYSA-N
  • MDL number
    MFCD00216817

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Saclofen

  • Proposed antagonists at GABAB receptors that inhibit adenylyl cyclase in cerebellar granule cell cultures of rat.

    Holopainen I et al (1992) Eur J Pharmacol 227(2) : 225-8.
    PubMedID: 1330652
  • Inhibition of baclofen binding to rat cerebellar membranes by phaclofen, saclofen, 3-aminopropylphosphonic acid and related GABAB receptor antagonists.

    Drew CA et al (1990) Neurosci Lett 113(1) : 107-10.
    PubMedID: 2164173
  • Antagonism at GABAB receptors by saclofen and related sulphonic analogues of baclofen and GABA.

    Kerr DI et al (1989) Neurosci Lett 107(1-3) : 239-44.
    PubMedID: 2559370

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