Product overview

Name Saclofen
Purity >99%
Description Selective, competitive GABAB receptor antagonist
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Biological Data

Biological description Selective and competitive GABAB receptor antagonist. Inhibits baclofen binding (IC50 = 7.8 µM).

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Molecular Weight 249.72
Chemical structure Saclofen  [125464-42-8] Chemical Structure
Molecular Formula C9H12ClNO3S
CAS Number 125464-42-8
PubChem identifier 122150
SMILES C1=CC(=CC=C1C(CN)CS(=O)(=O)O)Cl
InChi InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
InChiKey JYLNVJYYQQXNEK-UHFFFAOYSA-N
MDL number MFCD00216817

References for Saclofen

References are publications that support the biological activity of the product
  • Proposed antagonists at GABAB receptors that inhibit adenylyl cyclase in cerebellar granule cell cultures of rat.

    Holopainen I et al (1992) Eur J Pharmacol 227(2) : 225-8.
  • Inhibition of baclofen binding to rat cerebellar membranes by phaclofen, saclofen, 3-aminopropylphosphonic acid and related GABAB receptor antagonists.

    Drew CA et al (1990) Neurosci Lett 113(1) : 107-10.
  • Antagonism at GABAB receptors by saclofen and related sulphonic analogues of baclofen and GABA.

    Kerr DI et al (1989) Neurosci Lett 107(1-3) : 239-44.

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