Product overview

Name SAG
Purity >98%
Description Cell permeable Sonic hedgehog (Shh) agonist and Smo agonist. Enhances neuronal differentiation of iPSC into dopaminergic neurons.
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Biological Data

Biological description Potent, cell-permeable Smo receptor agonist (Kd = 59 nM) and hedgehog (Hh) signaling activator. Counteracts cyclopamine inhibition of Smo. Acts as an Smo activator at low concentrations and an inhibitor at high concentrations. Also enhances neuronal differentiation of iPSC into dopaminergic neurons.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name N-Methyl-N'-(3-pyridinylbenzyl)-N'-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane
Molecular Weight 490.1
Chemical structure SAG [912545-86-9] Chemical Structure
Molecular Formula C28H28ClN3OS
CAS Number 912545-86-9
PubChem identifier 5284330
SMILES ClC2=C(C(N([C@H]4CC[C@H](NC)CC4)CC3=CC=CC(C5=CC=NC=C5)=C3)=O)SC1=CC=CC=C12
InChiKey VFSUUTYAEQOIMW-YHBQERECSA-N
Appearance Off-white to light yellow powder