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Product overview

  • Name
  • Short description
    HDAC inhibitor
  • Biological description
    Class I and II histone deacetylase (HDAC) inhibitor (IC50 values are 10 and 20 nM for HDAC1 and HDAC3 respectively). Reduces pro-inflammatory cytokine production. Shows anti-inflammatory, anti-retroviral, growth inhibitory and anti-cancer actions.
  • Alternative names
    Vorinostat; Suberoylanilide hydroxamic acid
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    SAHA  [149647-78-9]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SAHA

  • Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.

    Butler LM et al (2000) Cancer Res 60(18) : 5165-70.
    PubMedID: 11016644
  • The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines.

    Leoni F et al (2002) Proc Natl Acad Sci U S A 99(5) : 2995-3000.
    PubMedID: 11867742
  • Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.

    Beckers T et al (2007) Int J Cancer 121(5) : 1138-48.
    PubMedID: 17455259
  • The histone deacetylase inhibitor vorinostat (SAHA) increases the susceptibility of uninfected CD4+ T cells to HIV by increasing the kinetics and efficiency of postentry viral events.

    Lucera MB et al (2014) J Virol 88(18) : 10803-12.
    PubMedID: 25008921
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