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Product overview

  • Name
  • Short description
    Selective elF2α dephosphorylation inhibitor
  • Biological description
    Selective eukaryotic translation initiation factor 2 subunit α (elF2α) dephosphorylation inhibitor. Inhibits protein phosphatase 1 (PP1) action on elF2α without inhibiting dephosphorylation of other PP1 substrates. Inhibit herpes simplex virus replication and protects cells from apoptosis through endoplasmic reticulum stress. Shows potential neuroprotective actions.
  • Alternative names
    eIF-2α Inhibitor
  • Biological action
  • Purity
  • Citations


  • Chemical name
    3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propen amide
  • Molecular Weight
  • Chemical structure
    Salubrinal  [405060-95-9]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Salubrinal

  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.

    Boyce M et al (2005) Science 307(5711) : 935-9.
    PubMedID: 15705855
  • A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death.

    Boyce M et al (2008) Cell Death Differ 15(3) : 589-99.
    PubMedID: 18188169
  • Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats.

    Cai XH et al (2014) Exp Neurol 257 : 148-56.
    PubMedID: 24810321
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