Product overview

Name Salubrinal
Alternative names eIF-2α Inhibitor
Purity >99%
Description Selective elF2α dephosphorylation inhibitor
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Biological Data

Biological description Selective eukaryotic translation initiation factor 2 subunit α (elF2α) dephosphorylation inhibitor. Inhibits protein phosphatase 1 (PP1) action on elF2α without inhibiting dephosphorylation of other PP1 substrates. Inhibit herpes simplex virus replication and protects cells from apoptosis through endoplasmic reticulum stress. Shows potential neuroprotective actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Chemical name 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propen amide
Molecular Weight 479.81
Chemical structure Salubrinal  [405060-95-9] Chemical Structure
Molecular Formula C21H17N4OSCl3
CAS Number 405060-95-9
PubChem identifier 5717801
SMILES S=C(NC(NC(/C=C/C3=CC=CC=C3)=O)C(Cl)(Cl)Cl)NC1=C2C(C=CC=N2)=CC=C1
InChiKey LCOIAYJMPKXARU-VAWYXSNFSA-N

References for Salubrinal

References are publications that support the biological activity of the product
  • Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats.

    Cai XH et al (2014) Exp Neurol 257 : 148-56.
  • A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death.

    Boyce M et al (2008) Cell Death Differ 15(3) : 589-99.
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.

    Boyce M et al (2005) Science 307(5711) : 935-9.

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