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SB 202190


Product overview

  • Name
    SB 202190
  • Short description
    Potent ATP competitive p38 MAPK inhibitor
  • Biological description
    Potent ATP competitive p38 MAPK inhibitor (IC50 values are 50 and 100 nM for p38α and p38β respectively). Inhibits TNF, IL-1 and CK1 (approx IC50 = 0.6 μM) therefore inhibits CREB phosphorylation. Exhibits little or no activity at CK2. Displays anti-inflammatory properties and induces apoptosis.
  • Alternative names
  • Biological action
  • Purity
  • Citations


  • Chemical name
    4-[4-(4-Fluorophenyl)-5-(4-pyridiny l)-1H-imidazol-2-yl]phenol
  • Molecular Weight
  • Chemical structure
    SB 202190  [152121-30-7]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SB 202190

  • Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190.

    Shanware NP et al (2009) BMB Rep 42(3) : 142-7.
    PubMedID: 19336000
  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.
    PubMedID: 10998351
  • Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase.

    Nemoto S et al (1998) J Biol Chem 273(26) : 16415-20.
    PubMedID: 9632706
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