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Product overview

  • Name
    SB 203580
  • Short description
    Potent, selective p38 MAPK inhibitor. Stimulates neural stem cell proliferation.
  • Biological description
    Potent and selective p38 MAPK inhibitor (IC50 values are 32.6 and 22.4 nM for active and inactive forms of p38 respectively). Exhibits higher selectivity for p38α over p38β (IC50 values are 50 and 500 nM respectively). Inhibits many kinases including tyrosine kinases p56 lck and c-src (IC50 = 5 µM) and also TNFα, IL-6, COX-1, COX-2. Also stimulates neural stem cell proliferation. Displays anti-inflammatory properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    SB 203580  [152121-47-6]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in DMSO (25mM) or HCl (100mM, 1eq. HCl)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SB 203580

  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.
    PubMedID: 10998351
  • Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle.

    Munoz L et al (2010) Eur J Pharmacol 635(1-3) : 212-8.
    PubMedID: 20226180
  • RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.

    Wadsworth SA et al (1999) J Pharmacol Exp Ther 291(2) : 680-7.
    PubMedID: 10525088
  • Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase.

    Börsch-Haubold AG et al (1998) J Biol Chem 273(44) : 28766-72.
    PubMedID: 9786874
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