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Biological Data
| Biological description | Potent and selective 5-HT2B receptor antagonist (pA2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT2C, 5-HT2A, 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors (pKi values are 5.82, ~5.2 at 5-HT2C amd 5-HT2A respectively. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (20mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-m ethyl-5-isothiazolyl)urea |
| Molecular Formula | C14H14N4OS |
| PubChem identifier | 3277600 |
| SMILES | O=C(NC3=CC(C)=NS3)NC1=CC(C=CN2C)=C2C=C1 |
| InChiKey | USFUFHFQWXDVMH-UHFFFAOYSA-N |
Potent, selective 5-HT2B receptor antagonist
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