In my cart

You have no items in your shopping cart.

Data

Product overview

  • Name
    SB 216763
  • Short description
    Potent, selective cell permeable GSK-3 inhibitor. Promotes mouse ESC pluripotency.
  • Biological description
    Potent and selective cell permeable, ATP competitive GSK-3 inhibitor (IC50 = 34 nM for GSK-3α). Equally effective at GSK-3α as GSK-3β. Displays little or no activity at 24 other serine/threonine and tyrosine protein kinases. Additionally stimulates glycogen synthesis (EC50 = 3.6 μM). Also promotes mouse embryonic stem cell pluripotency and displays anti-inflammatory and neuroprotective properties.
  • Alternative names
    SB-216763
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • Molecular Weight
    371.22
  • Molecular Formula
    C19H12Cl2N2O2
  • CAS Number
    280744-09-4
  • PubChem identifier
    176158
  • SMILES
    CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
  • InChiKey
    JCSGFHVFHSKIJH-UHFFFAOYSA-N
  • MDL number
    MFCD09753369
  • Appearance
    Orange solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (75mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SB 216763

  • Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.

    Coghlan MP et al (2000) Chem Biol 7(10) : 793-803.
    PubMedID: 11033082
  • 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.

    Gurrieri C et al (2010) J Pharmacol Exp Ther 332(3) : 785-94.
    PubMedID: 19959748
  • Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.

    Cross DA et al (2001) J Neurochem 77(1) : 94-102.
    PubMedID: 11279265
Support & Resources