SB 216763

(HB1272)

Product overview

  • Name
    SB 216763
  • Short description
    Potent, selective cell permeable GSK-3 inhibitor. Promotes mouse ESC pluripotency.
  • Biological description
    Potent and selective cell permeable, ATP competitive GSK-3 inhibitor (IC50 = 34 nM for GSK-3α). Equally effective at GSK-3α as GSK-3β. Displays little or no activity at 24 other serine/threonine and tyrosine protein kinases. Additionally stimulates glycogen synthesis (EC50 = 3.6 μM). Also promotes mouse embryonic stem cell pluripotency and displays anti-inflammatory and neuroprotective properties.
  • Alternative names
    SB-216763
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • Molecular Weight
    371.22
  • Molecular Formula
    C19H12Cl2N2O2
  • CAS Number
    280744-09-4

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (75mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SB 216763

  • Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.

    Coghlan MP et al (2000) Chem Biol 7(10) : 793-803.
    PubMedID: 11033082
  • 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.

    Gurrieri C et al (2010) J Pharmacol Exp Ther 332(3) : 785-94.
    PubMedID: 19959748
  • Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.

    Cross DA et al (2001) J Neurochem 77(1) : 94-102.
    PubMedID: 11279265