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SB 269970 hydrochloride

(HB1684)
Data

Product overview

  • Name
    SB 269970 hydrochloride
  • Short description
    Potent, selective 5-HT7 receptor antagonist
  • Biological description
    Potent and selective 5-HT7 receptor antagonist. Selective for for 5-HT7A over 5-HT5A and 5-HT1B (pKi values are 8.9, 7.2 and 6.0 respectively). Inhibits hyperactivity induced by amphetamine and ketamine. Blood-brain barrier permeable.
  • Alternative names
    SB-269970,SB269970
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride
  • Molecular Weight
    388.95
  • Chemical structure
    SB 269970 hydrochloride  [261901-57-9]
  • Molecular Formula
    C18H28N2O3S.HCl
  • CAS Number
    261901-57-9

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SB 269970 hydrochloride

  • Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist.

    Hagan JJ et al (2000) Br J Pharmacol 130(3) : 539-48.
    PubMedID: 10821781
  • Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity.

    Galici R et al (2008) Behav Pharmacol 19(2) : 153-9.
    PubMedID: 18332680
  • A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).

    Lovell PJ et al (2000) J Med Chem 43(3) : 342-5.
    PubMedID: 10669560
  • Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats.

    Nikiforuk A et al (2013) PLoS One 8(6) : e66695.
    PubMedID: 23776692
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